Publications

Refereed Research Papers

2025
Gorodetsky J; Monych N; Turner RJ; Haji-Ghassemi O; Booth SC Role of AprA and pyocyanin from Pseudomonas aeruginosa on Staphylococcus aureus tolerance to silver Microbiology. 171(9): 001596.
Stykel MG; Siripala SV; Soubeyrand E; Camargo S; Lu P; Coackley CL; Panchal R; So RWL; Stuart E; Joseph J; Akrioti EK; Haji-Ghassemi O; Taoufik E; Akhtar T; Watts JC; Ryan SD G6PD deficiency triggers dopamine loss and the initiation of Parkinson's disease pathogenesis Cell Reports. 44(1): 115178.
Yoo R*; Haji-Ghassemi O*; Bader M; Xu J; McFarlane C; van Petegem F Crystallographic, kinetic, and calorimetric investigation of PKA interactions with L-type calcium channels and Rad GTPase J Biol Chem. 301(1): 108039.
2024
Joseph TT; Bu W; Haji-Ghassemi O; Chen S; Woll K; Allen PD; Brannigan G; van Petegem F; Eckenhoff RG Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1) Br J Anaesth. 133(5): 1093-1100.
2023
Cholak S; Saville JW; Zhu X; Berezuk AM; Tuttle KS; Haji-Ghassemi O; Alvarado F; Van Petegem F; Subramaniam S Allosteric Modulation of Ryanodine Receptor RyR1 by Nucleotide Derivatives Structure. 31(7): 790-800.e4.
Haji-Ghassemi O; Yu SC; Woll K; Gurrola GB; Valdivia CR; Cai W; Li S; Valdivia HH; van Petegem F Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals a sub-conductance state that is abolished by PKA phosphorylation Sci Adv. 9(21): eadf4936.
2022
Qin J; Zhang J; Lin L; Haji-Ghassemi O; Lin Z; Woycechowsky KJ; Van Petegem F; Zhang Y; Yuchi Z Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy eLife. 11: e75346.
Rayani K; Hantz E; Haji-Ghassemi O; Yueh AL; Spuches A; Van Petegem F; Solaro JR; Lindert S; Tibbits GF The effect of magnesium on calcium binding to cardiac troponin C related hypertrophic cardiomyopathy mutants FEBS J. 289(23): 7446-7465.
2021
Woll KA*; Haji-Ghassemi O*; Van Petegem F Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM Nat Commun. 12(1): 1-13.
2020
Stringer RN; Jurkovicova-Tarabova B; Huang S; Haji-Ghassemi O; Idoux R; Liashenko A; Souza IA; Rzhepetskyy Y; Lacinova L; Van Petegem F; Zamponi GW; Pamphlett R; Weiss N A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity Mol Brain. 13(1): 1-11.
Ma R*; Haji-Ghassemi O*; Ma D*; Jiang H*; Lin L; Yao L; Samurkas A; Li Y; Wang Y; Cao P; Wu S; Zhang Y; Murayama T; Moussian B; Van Petegem F; Yuchi Z Structural basis for diamide modulation of ryanodine receptor Nat Chem Biol. 16(11): 1246-1254.
2019
Haji-Ghassemi O; Yuchi Z; Van Petegem F The cardiac ryanodine receptor phosphorylation hotspot embraces PKA in a phosphorylation-dependent manner Mol Cell. 75(1): 39-52.
2018
Haji-Ghassemi O; Müller-Loennies S; Brooks CL; MacKenzie CR; Caveney N; Van Petegem F; Brade L; Kosma P; Brade H; Evans SV Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude Biochemistry. 58(6): 714-726.
Roston T*; Haji-Ghassemi O*; LaPage MJ; Batra AS; Bar-Cohen Y; Anderson C; Lau YR; Maginot K; Gebauer RA; Etheridge SP; Potts JE; Van Petegem F; Sanatani S Catecholaminergic polymorphic ventricular tachycardia patients with multiple genetic variants in the PACES CPVT Registry Plos One. 13(11): e0205925.
Blackler RJ; López-Guzmán A; Hager FF; Janesch B; Martinz G; Gagnon SML; Haji-Ghassemi O; Kosma P; Messner P; Schäffer C; Evans SV Structural basis of cell wall anchoring by SLH domains in Paenibacillus alvei Nat Commun. 9(1): 3120.
Gagnon SML; Legg MSG; Polakowski R; Letts JA; Persson M; Lin S; Blake Zheng R; Rempel B; Schuman B; Haji-Ghassemi O; Borisova SN; Palcic MM; Evans SV Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases Glycobiology. 28(8): 624-636.
2016
Haji-Ghassemi O; Gilbert M; Spence J; Schur MJ; Parker MJ; Jenkins ML; Burke JE; van Faassen H; Young MN; Evans SV Molecular basis for recognition of the cancer glycobiomarker, GalNAc(β1-4)GlcNAc (LacdiNAc) by Wisteria floribunda agglutinin J Biol Chem. 291(46): 24085-24095.
Haji-Ghassemi O; Müller-Loennies S; Rodriguez T; Brade L; Grimmecke HD; Brade H; Evans SV The Combining Sites of Anti-lipid A Antibodies Reveal a Widely Utilized Motif Specific for Negatively Charged Group J Biol Chem. 291: 10104-10118.
2015
Haji-Ghassemi O; Müller-Loennies S; Rodriguez T; Brade L; Kosma P; Brade H; Evans SV Structural basis for antibody recognition of lipid A: insights to polyspecificity toward single stranded DNA J Biol Chem. 290: 19629-19640.
Haji-Ghassemi O; Blackler RJ; Young MN; Evans SV Antibody recognition of carbohydrate epitopes Glycobiology. 25(9): 920-952. [Review]
Gagnon SML; Meloncelli PJ; Zheng RB; Haji-Ghassemi O; Johal AR; Borisova SN; Lowary TL; Evans SV High resolution structures of the human ABO(H) blood group enzymes in complex with donor analogs reveal that the enzymes utilize multiple donor conformations to bind substrates in a step-wise manner J Biol Chem. 290(45): 27040-27052.
2014
Haji-Ghassemi O; Müller-Loennies S; Saldova R; Muniyappa M; Brade L; Rudd PM; Harvey DJ; Kosma P; Brade H; Evans SV Groove-type recognition of chlamydiaceae-specific lipopolysaccharide antigen by a family of antibodies possessing an unusual variable heavy chain N-linked glycan J Biol Chem. 289(24): 16644-16661.

Book Chapters

2017
Haji-Ghassemi O; Gagnon SML; Müller-Loennies S; Evans SV Polyspecificity of anti-lipid A antibodies and its relevance to the development of autoimmunity In: Protein Reviews. Adv Exp Med Biol. (18): 181-202. M. Zouhair Atassi (Ed.)

Patents

The application of diamide compounds for treatment of central core disease China. 21C52253. 2021/07/01. Patent Status: Pending